The street is a mixture of fine Georgian and Victorian houses. Florence Nightingale, founder of the famous school of nursing, lived at No.47. Before becoming the domain of private clinics, Harley Street was the home of a number of the nation's eminent people, such as Wellington (No.11), Turner (No.64), Gladstone and Allan Ramsay.

The «City»of London, to the north of the Thames was redeveloped in concrete and glass, but the old medieval face of the city is found amidst the intertwined streets, alleys and steps where you can leave the traffic congestion and discover old inns, statues and fountains. Destroyed by the Great Fire of 1666 and intersected by 19C avenues, the City was rebuilt after the 1941 bombing. It is now London's financial capital.

Laid out from 1717 onwards, Cavendish Square, its garden planted with majestic plane trees, still has some old buildings. Two houses in Palladian style are located on the north side (from No. 11 to No. 14) and date from the 1770s. Among the other 18C and 19C houses, No. 5 was occupied in 1787 by Nelson. In1788, Byron was born in the house today occupied by the John Lewis department store.

St Bartholomew's, commonly known as Barts was, like the priory, founded in 1123 by Rahere and has been modified many times. The main entrance is adorned with a statue of Henry VIII - the king who gave London this hospital. The North wing (1733), was built by Gibb, who was once a hospital governor, and accommodates a staircase and a hall (closed) decorated with paintings by Hogarth and portraits by Holbein, Kneller, Lawrence and Reynolds.